• A new RAS binding protein WDR76 functions as a tumor suppressor via RAS degradation.
  Jeong, WJ, Park, JC, Kim, WS, Ro, EJ, Jeon, SH, Lee, SK, Park YN, Min, DS, and Choi, K.
  Nature Communications. Accepted (2018)
• β-Catenin-RAS interaction serves as molecular switch for RAS degradation via GSK3β.
  Lee, SK, WJ, Cho, YH, Cha, PH, Yoon JS, Ro EJ, Choi SH, Oh, JM, Heo,YS, Kim H, Min, DS, Han, G, Lee, W, Choi. KY.
  EMBO Reports pii; e46060 (2018)
• A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab.
  Lee, SK, Choi YH, Cha, PH, Yoon JS, Ro, EJ, Jeong WJ, Park, JE, Kim, H, Kim TI, Min DS, Han G, and Choi. KY.
  Experimental & Molecular Medicine. (2018)
• Identification of Ras degrading small molecules inhibiting the transformation of colorectal cancer cells independently of β-catenin signaling.
  Shin, W., Lee, SK., Hwang, JH, Park JC, Choi, YH, Ro EJ, Song Y, Seo HR., and Choi, KY.
  Experimental & Molecular Medicine. 50, 71. (2018)
• Discovery of A Small-Molecule Inhibitor of Dvl CXXC5 Interaction by Computational Approaches.
  Ma, S, Choi, J, Jin, X, Kim, HY, Yun, JH, Lee, W, Choi, KY, No, KT. 
  Journal of Computer-Aided Molecular Design. 32: 643-655. (2018)
• Interaction between Wnt/β-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of β-catenin and RAS by targeting the Wnt/β-catenin pathway.
  Jeong WJ, Ro EJ, Choi. KY.
  Npj Precision Oncology. 2, article number 5 (2018)
• Transcutaneous implantation of valproic acid-encapsulated dissolving microneedles induces hair regrowth Biometrials.
  Lahiji, SF. Seo, SH., Kim, S., Dangol, M., Shim, J., Li, CG., Ma, Y., Lee, C., Kang, G., Yang, H., Choi, K.Y., Jung H.
  160, 69-79. (2018).
•  Interaction of the Wnt/β-catenin and RAS-ERK pathways involving co-stabilization of both β-catenin and RAS plays important roles in the colorectal tumorigenesis.
  Lee, SK., Hwang, JH., Choi. KY.
  Advances in Biological regulation.  pii: S2212-4926(18)30002-2. (2018).​
• A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer.
  Park, J, Cho, YH, Shin, WJ, Lee, JH, Lee, SK, Kim, TH, Cha, PH, Yang, JS, Cho, J, Min, DS, Han, G, Lee, HY, and Choi, KY. 
  Scientific Reports. Accepted. (2018)

• ​Targeting of CXXC5 by a Competing Peptide Stimulates Hair Re-growth and Wound-Induced Hair Neogenesis.
  Lee SH, Seo SH, Lee DH, Pi LQ, Lee WS, Choi KY.
  Journal of Investigative Dermatology. Accepted (2017)
• Screening-based approaches to identify small molecules that inhibit protein-protein interactions.
  Choi S, Choi KY. Expert Opininon on Drug Discovery. 2017, 12:293-303
• Phospholipase D1 inhibition linked to upregulation of ICAT blocks colorectal cancer growth hyperactivated by Wnt/β-catenin and PI3K/Akt Signaling.
  Kang, DW, Lee, BH, Suh, Y-A, Choi, Y-S. Jang, SJ, Kim, Y-M, Choi, KY., Min DS. 
  Clinical Cancer Res. 23, 7340-7350. (2017)
• Stabilization of Sur8 via PKCα/δ degradation promotes transformation and migration of colorectal cancer cells.
  Lee KH, Jeong, WJ, Cha, PH, Lee, SK, Min DS, Choi, KY.
  Oncotarget. 8, 115596-115608. (2017).
• MicroRNA-320a and -4496 attenuate Helicobacter pylori CagA-induced cancer-initiating potential and chemo-resistance by targeting β-catenin and ABCG2.
  Kang, DW, Yang, ES, Noh, YN, Hwang, WC, Jo SY, Suh, YA, Park, WS, Choi, KY, Min, DS.
  Journal of Pathology. 241, 614-625. (2017).
• Phospholipase D1 acts through Akt/TopB1 and RB1 to regulate the E2F1-dependent apoptotic program in cancer cells.
  Kang, DW., Lee, SW, Hwang, WC, Lee, BH, Choi, YS, Suh, YA, Choi, KY., Min, DS.
  Cancer Research. 77, 142-152. (2017).
• Crystal structure of the PDZ domain of mouse Dishevelled 1 and its interaction with CXXC5. Biochem. Biophys. Res.
  Lee, I, Choi, S, Yun, JH, Seo, S, Choi, S, Choi, KY, Lee, W.
  Commun. 485, 584-590. (2017).
• Small molecule binding of the Axin-RGS domain promotes β-catenin and Ras degradation.
  Cha PH, Cho YH, Lee SK, Lee JH, Jeong W-J, Moon B-S, Yun JH, Yang JS, Choi SH, Yoon JY, Kim HY, Kim, MY, Kaduwal S, Lee W, Min DS, Kim Hg, Han GH, and Choi KY.
  Nature Chemical Biology. 12, 593-600. (2016).
• KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer.
  Cho YH, Cha P, Kaduwal S, Park JC, Lee SK, Yoon JS, Shin W, Kim H, Ro EJ, Koo KH, Park KS, Han GH and Choi, KY.
  Oncotarget. 7, 81727-81740. (2017)

• KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer.
  Cho YH, Cha P, Kaduwal S, Park JC, Lee SK, Yoon JS, Shin W., Kim H, Ro EJ, Koo KH, Park KS, Han GH, and Choi, KY.
  Oncotarget. 2016, 7(49):81727-81740
• Small molecule binding of the Axin-RGS domain promotes β-catenin and Ras degradation.
  Cha PH, Cho YH, Lee SK, Lee JH, Jeong W-J, Moon B-S, Yun JH, Yang JS, Choi SH, Yoon JY, Kim HY, Kim, MY, Kaduwal S, Lee W, Min DS, Kim Hg, Han GH, and Choi KY.
  Nature Chemical Biology. 2016, 12(8):593-600
• Small molecule inhibitors of Dishevelled-CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy.
  Kim, HY, Choi, S, Yoon JH, Lim HJ, Lee H, Choi J, Neo JN, Lee W, No, KT, and Choi KY.
  EMBO Molecular Medicine. 2016, 8:375-387
• CXXC5 plays a role as a transcription activator for myelin genes on oligodendrocyte differentiation.
  Kim, MY., Kim HY, Hong J., Kim D, Lee H, Cheong, E., Lee, Yangsin, Roth J., Kim, DG, Min DS., and Choi KY.
  Glia. 2016, 64(3):350-362
• Retinoic Acid-Mediated HRas Stabilization Induces Neuronal Differentiation of Neural Stem Cells during Brain Development.
  Park JC, Jeong WJ, Kim MY, Min DS, and Choi KY.
  Journal of Cell Science. 2016, 129:2997-3007
• Sur8 mediates tumorigenesis and metastasis in colorectal cancer.
  Lee, YM, Kaduwal S, Lee KH, Park JC, Jeong WJ, and Choi KY.
  Experimental Molecular Medicine. 2016, 48(7):e249
• Polygonum aviculare L. and its active compounds, quercitrin hydrate, caffeic acid, and rutin, activate the Wnt/β-catenin pathway and induce cutaneous wound healing.
  Seo, SH., Lee, SH, Cha, PH, Kim, MY, Min, DS, Choi KY.
  Phytotherapy Research. 2016, 30:848-854.
• Simultaneous destabilization of β-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer.
  Cha, P.H., and Choi, K.Y.
  BMB Report. 2016, 49:455-456

• The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing.
  Lee SH, Kim MY, Kim HY, Lee YM, Kim H, Nam KA, Roh MR, Chung KY, Choi KY.
  Journal of Experimental Medicine 2015, 212(7):1061-1080
• K-Ras stabilization by estrogen via PKCd is involved in endometrial tumorigenesis.
  Koo KH, Jeong WJ, Choi YH, Park JC, Min DS, Choi KY.
  Oncotarget 2015, 6(25):21328-21340
• Targeting phospholipaseD1 attenuates intestinal tumorigenesis by controlling β-catenin signaling in cancer-initiating cells.
  Kang DW, Choi CY, Cho YH, Tian H, Di Paolo G, Choi KY, Min DS.
  Journal of Experimental Medicine 2015, 212:1219-1237
• CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation.
  Kim HY, Yoon JY, Yoon JH, Cho KW, Lee SH, Rhee YM, Jung HS, Lim HJ, Choi JW, Heo JN, Lee WT, No KT, Min DS, Choi KY.
  Cell Death and Differentiation 2015, 22:912-920
• Phospholipase D2 promotes degradation of hypoxia-inducible factor-1a, independent of lipase activity.
  Park MH, Bae SS, Choi KY, and Min DS.
  Experimental and Molecular Medicine. 2015, 47:e196
• Euodia sutchuenensis Dode extract stimulates osteoblast differentiation via Wnt/beta-catenin pathway activation.
  Hwang JH, Cha PH, Han G, Bach TT, Min DS, Choi KY.
  Experimental and Molecular Medicine. 2015, 47:e152
• NNC 55-0396, a T-type Ca2+ channel inhibitor, inhibits angiogenesis via suppression of hypoxia-inducible factor-1.
  Kim KH, Kim DY, Park JY, Jung HJ, Cho YH, Kim HK, Han J, Choi KY, Kwon HJ.
  Journal of  Molecular Medicine. 2015, 93:5

 Editorial Reviewed by Eric Feron

•  Oncogenic K-Ras Accelerates Cancer Stem Cell Activation via Aberrant Wnt/β-catenin Signaling.
  Moon BS, Jeong WJ, Park J, Kim TI, Min DS, Choi KY.
  Journal of the National Cancer Institute 2014 106:1-10
• Response to Cristobal.
  Moon BS, Cho YH, Jeong WJ, Choi KY.
  JNCI-Journal of the National Cancer Institute. 2014 8:1
• CXXC5 is a transcriptional activator of Flk-1 and mediates bone morphogenic protein-inducedendothelial cell differentiation and vessel formation.
  Kim HY, Yang DH, Shin SW, Kim MY, Yoon JH, Kim S, Park HC, Kang DW, Min DS, Hur MW, Choi KY.
  FASEB J 2014 28:615-626
• Indirubin-3’-oxime Reverses Bone Loss in Ovariectomized and Hindlimb-Unloaded Mice via Activation of the Wnt/β-Catenin Signaling.
  Zahoor, M, Cha PH, Min DS, Choi KY.
  Journal of Bone and Mineral Research 2014 29:1196-1205
• The small molecule indirubin-3´-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity.
  Olivia Choi, Yong-Hee Cho, Sena Choi, Soung-Hoon Lee, Seol Wha Seo, Hyun-Yi Kim, Gyoonhee Han, Taesun Park, Do Sik Min, and Kang-Yell Choi.
  International Journal of Obesity. 2014 38:1044-1052
• Indirubin-3′-oxime, an activator of Wnt/β-catenin signaling, enhances osteogenic commitment of ST2 cells and restores bone loss in high-fat diet-induced obese male mice.
  Zahoor M, Cha PH, Choi KY.
  Bone 2014 65:60-68
• Hovenia Dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice.
  Cha PH, Shin W, Zahoor M, Kim HY, Min DS, Choi KY.
  PLOS ONE 2014 22:e85546

Selected as a featured article on MDLinx on 9th of August

• Strategies to overcome resistance to EGFR monoclonal antibody therapy in metastatic colorectal cancers.
  Jeong WJ, Cha PH, Choi KY.
  World Journal of Gastroenterology 2014 20:9862-9871