skip to Main Content


For a better quality of human life.


(주)씨케이바이오텍 주요 논문

2020-01-03 18:03
1. Park, JC, Jeong, W-J, Seo, SW, and Choi, KY. WDR76 mediates obesity and hepatic steatosis via HRas destabilization. Scientific Reports. 9(1):19676. doi: 10.1038/s41598-019-56211-6. (2019).

2. Jeong, WJ, Park, JC, Kim, WS, Ro, EJ, Jeon, SH, Lee, SK, Park YN, Min, DS, and Choi, K.Y. WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation. Nature Communications. 10(1):295. (2019)

3. Choi, SE, Kim, HY, Cha, PH, Seo, SH, Lee C, Choi, Y, Shin W, Heo, Y, Han GH, Lee WT. and Choi, K.Y. CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth. Life Science Alliance. 2(2). pii: e201800254. (2019)

4. Park, J, Cho, YH, Shin, WJ, Lee, JH, Lee, SK, Kim, TH, Cha, PH, Yang, JS, Cho, J, Min, DS, Han, G, Lee, HY, and Choi, KY. A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer. Scientific Reports. 9(1):648. (2019).

5. Lee, SH, Seo, SH, Lee DH, Pi, L-Q, Lee, WS, and Choi, KY. Targeting of CXXC5 by a competing peptide stimulates hair re-growth and wound-induced hair neogenesis. Journal of Investigative Dermatology. 137, 2260-2269 (2017).

6. Lee SH, Kim MY, Kim HY, Lee YM, Kim HS, Nam KA, Roh MR, Min DS, Chung KY, and Choi KY. The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing. Journal of Experimental Medicine. 29; 212(7):1061-80. (2015).

7. Choi, S. and Choi, KY. Screening-based approaches to identify small molecules that inhibit protein–protein interaction. Expert Opin. Drug Discovery. 12, 293-303. (2017).

8. Cha PH, Cho YH, Lee SK, Lee JH, Jeong W-J, Moon B-S, Yun JH, Yang JS, Choi SH, Yoon JY, Kim HY, Kim, MY, Kaduwal S, Lee W, Min DS, Kim Hg, Han GH, and Choi KY. Small molecule binding of the Axin-RGS domain promotes β-catenin and Ras degradation. Nature Chemical Biology. 12, 593-600. (2016).

9. Kim, HY, Choi, S, Yoon JH, Lim HJ, Lee H, Choi J, Neo JN, Lee W, No, KT, and Choi, KY. Small molecule inhibitors of Dishevelled-CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy. EMBO Molecular Medicine 8, 375-387 (2016).

10. Kim, MY., Kim HY, Hong J., Kim D, Lee H, Cheong, E., Lee, Yangsin, Roth J., Kim, DG, Min DS., and Choi, KY. CXXC5 plays a role as a transcription activator for myelin genes on oligodendrocyte differentiation. Glia. 64(3), 350-362. (2016).

11. Kim HY, Yoon JY, Yoon JH, Cho KW, Lee, SH, Rhee, YM, Jung, HS, Lim HJ, Choi, JW, Heo JN, Lee WT, No KT, Min DS, and Choi KY. CXXC5 is a negative-feedback regulator of the Wnt/β-catenin pathway involved in osteoblast differentiation. Cell Death and Differentiation. 22(6):912-20. (2015)

12. Moon, BS, Jeong, WJ, Park, J, Kim, TI, Min DS, and Choi, KY. Oncogenic K-Ras Accelerates Cancer Stem Cell Activation via Aberrant Wnt/beta-catenin Signaling. JNCI-Journal of the National Cancer Institute. 106(2):djt 373. (2014)

13. Moon BS, Cho YH, Jeong WJ, and Choi KY*. Response (RE; Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/β-catenin signaling). JNCI-Journal of the National Cancer Institute. 106 (8): dju 197. (2014)

14. Kim, HY, Yang, DH, Shin, SW, Kim, MY, Yoon, JH, Kim, S., Park, HC, Kang, DW, Min, DS, Hur, MW, and Choi, KY. CXXC5 is a transcriptional activator of Flk-1 and mediates bone morphogenic protein-induced endothelial cell differentiation and vessel formation. FASEB Journal. 28(2), 615-26 (2014)

15. Zahoor, M, Cha, BH, Min DS, Choi, KY. Indirubin-3’-oxime Reverses Bone Loss in Ovariectomized and Hindlimb-Unloaded Mice via Activation of the Wnt/β-Catenin Signaling. Journal of Bone and Mineral Research. 29, 1196-1205. (2014)

16. Olivia Choi, Yong-Hee Cho, Sena Choi, Soung-Hoon Lee, Seol Wha Seo, Hyun-Yi Kim, Gyoonhee Han, Taesun Park, Do Sik Min, and Kang-Yell Choi. The small molecule indirubin-3´-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity. International Journal of Obesity. (2014) 38, 1044-52.

17. Zahoor M, Cha PH, Choi KY. Indirubin-3'-Oxime, an activator of Wnt/b-catenin signaling, enhances osteogenic commitment of ST2 cells and restore bone loss in high-fat diet-induced obese male mice. Choi KY. Bone. 65, 60-68. (2014)
Back To Top